Search results for "electroretinography: non-clinical"
showing 3 items of 3 documents
Time course of IOP elevation, electroretinographic changes and retinal ganglion cell loss in a rat model of glaucoma induced by laser
2007
International audience; Purpose: To evaluate the time course of intraocular pressure (IOP) elevation, electroretinographic changes and retinal ganglion cell (RGC) loss in a rat model of glaucoma induced by photocoagulation of the trabeculum and the episcleral and limbal veins. Methods: Male Sprague Dawley rats were used at 6 weeks of age. At least 3 of the episcleral veins, the trabeculum and the limbal veins were photocoagulated with a laser at 532nm (Quantel Medical, Vitra) in one eye of the animals. IOP and electroretinogram (ERG) were monitored every 2 weeks during 11 weeks after photocoagulation. Three months after laser photocoagulation, the RGC population was identified with a 5% Flu…
Effect of intravitreal injection of Indocyanine Green, Triamcinolone Acetonide and Trypan Blue on the electroretinographic response of rats
2007
International audience; Purpose:: Indocyanine Green (ICG) and Tripan Blue (TB) are commonly used in macular surgery by making easier the internal limiting membrane (ILM) removing. However, the innocuousness of these dyes is not actually established notably for ICG. Then, several authors proposed the use of triamcinolone acetonide (TA) as an alternative to the use of intraoperative dyes for visualizing the ILM. The purpose of this study was to evaluate the effects of intravitreal injection of ICG, TB and TA on the rat electroretinogram (ERG). Methods:: Three groups of 12-week-old Sprague Dawley rats (n=6) received intravitreal injection in one eye of 0.1mL of either ICG 0.5mg/mL, TB 3mg/mL o…
Maternal n-3 long chain polyunsaturated fatty acids increase n-3 fatty acids in brain glial cells and retina in the rat and improve rod sensitivity
2007
International audience; Purpose: To evaluate the efficacy of long chain n-3 polyunsaturated fatty acids (LC-PUFA) given to female rats during gestation and lactation on the incorporation of n-3 PUFA in the retina and brain glial cells of the newborn rat, and to evaluate the consequences on the electroretinographic (ERG) response. Methods: Sprague Dawley rats were fed during gestation and lactation with a 20%-lipid rich diet containing 0.75% of EPA and 0.55% of DHA. The fatty acid profile was analyzed in the eyeball and in brain glial cells of the litters sacrificed at birth. The retina and brain glial cell phospholipids were similarly analyzed in 14 day-old rats and in the mothers. Standard…